Process for converting an alcohol to the corresponding fluoride

Details Process for converting an alcohol to the corresponding fluoride Process for converting an alcohol to the corresponding fluoride

C - Chemistry, Metallurgy

07

B

C07B 39/00 (2006.01) C07C 17/16 (2006.01) C07C 41/22 (2006.01) C07D 239/26 (2006.01)

Patent

CA 2615692

The invention provides a process for preparing a fluoride from its corresponding alcohol comprising the steps of (a) forming a mixture comprising (i) at least one primary or secondary alcohol and (ii) a molar excess of at least one strong, aprotic, non-nucleophilic, hindered, double bond--containing, organic base, said molar excess being less than 2 equivalents of said base per equivalent of said alcohol; and (b) adding at least one fluorinated, saturated aliphatic or alicyclic sulfonyl fluoride to said mixture.

L'invention a pour objet un procédé de préparation d'un fluorure à partir de l'alcool correspondant comprenant les étapes suivantes : a) formation d'un mélange constitué d'au moins un alcool primaire ou secondaire et d'un excédent molaire d'au moins une base organique forte, aprotique, non nucléophile, contenant une double liaison et à inhibition stérique, cet excédent moléculaire ne dépassant pas 2 équivalents de ladite base par équivalent dudit alcool; et b) addition audit mélange d'au moins un sulfonylfluorure aliphatique ou alicyclique saturé fluoré.

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