Process for converting the carbonyl function in position 4"...

Details Process for converting the carbonyl function in position 4"... Process for converting the carbonyl function in position 4"...

C - Chemistry, Metallurgy

07

H

C07H 17/00 (2006.01) A61K 31/7048 (2006.01) A61P 31/04 (2006.01) C07H 17/08 (2006.01)

Patent

CA 2410745

The invention relates to a process for preparing compound of general formula I (see formula I) by reductive amination of the corresponding (4")-carbonyl derivative, characterized in that it comprises: - placing the said (4")-carbonyl derivative in contact with at least one nitrogenous reagent and a Lewis acid under conditions that are favourable for converting the 4" carbonyl function, - reducing the resulting mixture using a reducing agent, and - optionally deprotecting the hydroxyl function in position 2', to give the expected compound of general formula I.

L'invention a pour objet un procédé de préparation d'un composé de formule générale (I) par animation réductrice du dérivé (4")-carbonyle correspondant, caractérisé en ce qu'il comprend: la mise en présence dudit dérivé (4")-carbonyle avec au moins un réactif azoté et un acide de Lewis dans des conditions favorables à la transformation de la fonction carbonyle 4"; la réduction du mélange résultant à l'aide d'un agent réducteur; et la déprotection éventuelle de la fonction hydroxyle en position 2', pour conduire au composé de formule générale (I) attendu.

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