C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
260/212, 530/17.
C08B 37/08 (2006.01) A61L 33/00 (2006.01) A61L 33/08 (2006.01) B01J 20/32 (2006.01) C08B 37/00 (2006.01) C08B 37/10 (2006.01)
Patent
CA 1227480
ABSTRACT. A process to produce by covalent binding con- jugates of a substance containing a 2-amino-2-deoxy- glycopyranosyl residue the NH2-function of which in its most stable conformation is equatorially oriented, and a substrate containing a primary amino group. This is done by subjecting the substance to degradation by diazo- tation to form a substance fragment having a free terminal aldehydo group, said fragment through its aldehydo group being reacted with the amino group of the substrate to form a Schiffs base which is then by reduction converted to a secondary amine. The substance is preferably selected from oligo and polysaccharides containing glucosamine or galactose amine units. The substrate is suitably selected from surface-aminated plastic objects, aminated gels and proteins. The conjugate described consists of an 1-deoxy- -2,5-anhydrohexitol unit which constitutes terminal unit in an oligo or polysaccharide and which in 1-position is covalently bound to an amino group associated with a substrate.
427944
Fetherstonhaugh & Co.
Larm Olle
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