C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/52 (2006.01)
Patent
CA 2554199
The present invention relates to a novel method for obtaining (2S,3aS,6aS)-1- [(S)-2-[[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-amino] propanoyl] octahydro cyclopenta[b] pyrrole-2-carboxylic acid, viz. Ramipril(I) in high optical purity, free of other stereoisomers, and in high bulk density. The present invention also relates to a novel hydrated form of Ramipril(I) and a process for preparation thereof.
L'invention concerne un procédé d'élaboration d'acide (2S,3aS,6aS)-1-[(S)-2-[[(S)-1-(éthoxycarbonyle)-3-phénylpropyle]-amino] propanoyle] octahydro cyclopenta[b] pyrrole-2-carboxylique, à savoir Ramipril(I), de pureté optique élevée, sans autres stéréoisomères, et de poids volumétrique élevé. L'invention concerne également une forme hydratée de Ramipril(I) et un procédé d'élaboration correspondant.
Dhake Vilas Nathu
Rananaware Umesh Babanrao
Singh Girij Pal
Lupin Limited
Riches Mckenzie & Herbert Llp
LandOfFree
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