Process for demineralization of bone matrix with...

A - Human Necessities – 61 – L

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A61L 27/36 (2006.01) A61F 2/28 (2006.01) A61F 2/30 (2006.01) A61L 27/28 (2006.01) A61L 27/40 (2006.01) A61L 27/54 (2006.01)

Patent

CA 2695492

A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.

L'invention concerne une matrice osseuse déminéralisée qui est produite par un procédé dans lequel un corps osseux est placé dans une première solution de traitement comprenant un acide pour déminéraliser le corps osseux. Le corps osseux est périodiquement retiré de la première solution à des intervalles de temps spécifiques pour effectuer au moins un essai, tel qu'un essai de compression, concernant une propriété mécanique du corps osseux. Quand l'essai donne le résultat souhaité, le corps osseux est exposé à une seconde solution de traitement qui est moins acide que la première, minimisant ainsi l'exposition du corps osseux aux conditions acides sévères de la phase de déminéralisation du procédé.

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