C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
167/45
C12Q 1/34 (2006.01) C12Q 1/37 (2006.01) C12Q 1/56 (2006.01) G01N 33/535 (2006.01) G01N 33/573 (2006.01) G01N 33/86 (2006.01)
Patent
CA 1176560
HOE 80/B 018 Abstract of the disclosure: This invention relates to methods for detecting, iden- tifying and quantifying enzymes, for example, human pro- teolytic enzymes. The method broadly comprises forming an immobilized or insoluble complex comprising enzyme, enzyme inhibitor and enzyme inhibitor-antibody reactive site and then detecting and identifying, preferably quan- titatively, one or more enzymes bound to the complex. In a preferred embodiment, a matrix, e.g. solid or semisolid surface or permeable matrix, has affixed thereto enzyme inhibitor-antibody or an immunologically active (inhibitor binding) fragment of such an antibody. This insoluble enzyme inhibitor interacting matrix is then con- tacted with biological fluid, e.g. body fluid, to bind one or more predetermined enzyme inhibitor-enzyme complexes, if present in the biological fluid. The bound enzyme is then detected, identified and preferably quantified.
386866
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cornell Research Foundation Inc.
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