Process for differential diagnosis of alzheimer's dementia...

Details Process for differential diagnosis of alzheimer's dementia... Process for differential diagnosis of alzheimer's dementia...

G - Physics

01

N

G01N 33/68 (2006.01) C07K 16/40 (2006.01) C12N 5/12 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2445367

A method for diagnosing Alzheimer's disease(AD) is disclosed. The method involves directly detecting the presence of a biochemical marker, specifically human glutamine synthetase, in bodily fluid, preferably blood or a blood product. The detection is by an immunoassay incorporating an antibody specific to human glutamine synthetase. In addition, a method for distinguishing between AD and non-AD dementia is disclosed.

L'invention concerne un procédé pour diagnostiquer la maladie d'Alzheimer (AD). Ce procédé consiste à détecter directement la présence d'un marqueur biochimique, en particulier la glutamine synthétase humaine, dans un fluide corporel, de préférence le sang ou un produit sanguin. La détection se fait par un essai immunologique comprenant un anticorps spécifique à la glutamine synthétase humaine. L'invention concerne par ailleurs un procédé permettant de différencier une démence de type Alzheimer d'une autre démence.

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