Process for enzyme inhibitors

Details Process for enzyme inhibitors Process for enzyme inhibitors

C - Chemistry, Metallurgy

12

N

195/122.5, 260/2

C12N 9/99 (2006.01) C07D 455/02 (2006.01) C07D 471/04 (2006.01) C12P 17/18 (2006.01)

Patent

CA 1211732

ABSTRACT Angiotensin I converting enzyme inhibitor A-58365 factor A is produced in enhanced yields by culturing Streptomyces chromofuscus NRRL 15098 under submerged aerobic fermentation conditions in a proline supplemented aqueous nutrient culture medium containing assimilable sources of carbon, nitrogen and inorganic salts.

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