C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 5/077 (2010.01) A61K 35/32 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2395957
The present invention concerns methods for the ex vivo formation of mammalian bone and subsequent uses of the bone. A critical and distinguishing feature of the present invention are defined tissue culture conditions and factors resulting in the formation of bone cell spheroids. The invention also provides for methods of implanting into subjects the ex vivo formed bone. Also described are methods for genetically altering the bone cell spheroids to affect bone formation, identification of candidate modulators of bone formation, and identification of genes involved in bone formation.
La présente invention concerne des méthodes de formation ex vivo d'os mammalien et les utilisations subséquentes dudit os. Un aspect critique et notable de l'invention se rapporte aux conditions et facteurs de culture tissulaire déterminés donnant lieu à la formation de sphéroïdes de cellules osseuses. L'invention concerne en outre des méthodes permettant d'implanter, chez un sujet, ledit os formé ex vivo. Elle concerne enfin des méthodes permettant de modifier génétiquement les sphéroïdes de cellules osseuses pour influer sur la formation osseuse, d'identifier des modulateurs candidats de la formation osseuse ainsi que des gènes intervenant dans la formation osseuse.
Kale Sujata
Long Michael W.
Goudreau Gage Dubuc
The Regents Of The University Of Michigan
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