Process for folding chemically synthesized polypeptides

Details Process for folding chemically synthesized polypeptides Process for folding chemically synthesized polypeptides

C - Chemistry, Metallurgy

07

K

C07K 1/113 (2006.01) C07K 1/04 (2006.01)

Patent

CA 2416054

The present invention relates to a process for folding chemically synthesized polypeptides, comprising treating a polypeptide and/or protein that comprises two or more derivatized cysteine residues with a reducing agent in a folding buffer having a predetermined pH and temperature, wherein the derivatized cysteine residue corresponds to S-butyl-thio-cysteine residue and wherein the reducing agent is cysteine.

La présente invention concerne un procédé de pliage de polypeptides chimiquement synthétisés, consistant à traiter un polypeptide et/ou une protéine comprenant au moins deux résidus de cystéine dérivatisés avec un agent réducteur dans un tampon de pliage présentant un pH et une température prédéterminés, le résidu de cystéine dérivatisé correspondant à un résidu de S-butyl-thio-cystéine, et l'agent réducteur étant de la cystéine.

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