Process for forming amorphous atorvastatin

Details Process for forming amorphous atorvastatin Process for forming amorphous atorvastatin

A - Human Necessities

61

K

A61K 9/19 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2585836

A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.

L'invention concerne un procédé de formation d'atorvastatine amorphe, lequel comprend les étapes consistant à dissoudre l'atorvastatine dans un solvant non-hydroxylique et à éliminer le solvant par cryodessiccation. L'invention concerne également des procédés consistant à dissoudre l'atorvastatine dans un solvant hydroxylique avec un agent de solubilisation, un agent alcalinisant ou un antioxydant et à éliminer le solvant par cryodessiccation pour pouvoir obtenir l'atorvastatine amorphe.

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