Process for forming amorphous atorvastatin calcium

Details Process for forming amorphous atorvastatin calcium Process for forming amorphous atorvastatin calcium

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2562844

Forming amorphous atorvastatin calcium comprises the steps of dissolving atorvastatin calcium in a solvent to form a solution, followed by adding the solution to a mixture comprising a non-solvent and a hydroxylic solvent to afford amorphous atorvastatin.

L'invention concerne un procédé pour former de l'atorvastatine calcique amorphe, comprenant les étapes qui consistent : à dissoudre de l'atorvastatine calcique dans un solvant pour former une solution, puis ; à ajouter la solution obtenue à un mélange comprenant un non-solvant et un solvant hydroxylique pour produire de l'atorvastatine amorphe.

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