C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/37 (2006.01) C12N 9/50 (2006.01) C12N 9/60 (2006.01)
Patent
CA 2485452
A process for generating sequence-specific proteases by screening-based directed evolution is disclosed. The use of the process provides proteases recognizing and cleaving user-definable amino-acid sequences with high sequence-specificity. Proteases obtainable by the process can be used in a variety of medical, diagnostic and industrial applications.
L'invention concerne un procédé de production de protéases à séquences spécifiques par évolution dirigée se basant sur le criblage. L'utilisation de ce procédé permet d'obtenir des protéases reconnaissant et coupant des séquences d'acides aminés définissables par l'utilisateur avec une grande spécificité de séquences. Des protéases pouvant être obtenues à l'aide de ce procédé peuvent être utilisées dans diverses applications médicales, diagnostiques et industrielles.
Haupts Ulrich
Kettling Ulrich
Koltermann Andre
Pilling Jens
Rarbach Markus
Bayer Schering Pharma Aktiengesellschaft
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Direvo Biotech Ag
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