C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2175482
The present invention relates to a method for generating an antibody which is specific for an immunorecessive epitope, and nucleic acid encoding the antibody. The Subject method generally comprises the steps of generating a variegated display library of antibody variable regions and selecting from the library those antibody variable regions which have a desired binding specificity for the immunorecessive epitope. The antibody variable regions used to generate the display library are cloned from an immunotolerance-derived antibody repertoire.
L'invention concerne un procédé pour générer un anticorps spécifique d'un épitope immunorécessif et un acide nucléique codant l'anticorps. Ce procédé consiste généralement à générer une bibliothèque de visualisation diversifiée de zones variables d'anticorps et à sélectionner dans cette bibliothèque les zones qui présentent une spécificité de liaison requise pour l'épitope immunorécessif. Les zones variables d'anticorps utilisées pour générer la bibliothèque de visualisation sont clonées à partir d'un répertoire d'anticorps dérivés de l'immunotolérance.
Barsomian Gary
Copeland Diane P.
Hillhouse Dana
Johnson Tracy
Genzyme Corporation
Smart & Biggar
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