C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2419894
The invention pertains to murine TLR9 and related TLR9s which include murine- specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR9. The invention further relates to methods of using such murine and non-murine TLR9 nucleic acids and polypeptides, especially in methods for screening for agonists and antagonists of immunostimulatory CpG nucleic acids. Also included are murine TLR9 inhibitors which inhibit murine TLR9 activity by inhibiting the expression or function of murine TLR9. In a further aspect the present invention pertains to murine TLR7 and murine TLR8, as well as related TLR7 and TLR8 molecules which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR7 and TLR8. Methods are included for screening for ligands of TLR7 and TLR8, as well as for inhibitors and agonists and antagonists of signaling mediated by TLR7 and TLR8.
L'invention concerne le TLR9 murin et des TLR9 apparentés contenant des acides aminés spécifiquement murins, ainsi que des acides nucléiques codant ces polypeptides. La présente invention concerne également des fragments et des variants biofonctionnels du TLR9 murin. L'invention concerne aussi des méthodes d'utilisation de ces acides nucléiques et polypeptides TLR9 murin et non murins, en particulier dans des méthodes de criblage d'agonistes et d'antagonistes d'acides nucléiques CpG immunostimulateurs. L'invention concerne également des inhibiteurs de TLR9 murins lesquels inhibent l'activité du TLR9 murin par inhibition de l'expression ou de la fonction du TLR9 murin. Dans un autre aspect, l'invention a trait au TLR7 murin et au TLR8 murin, de même qu'aux molécules de TLR7 et TLR8 associées lesquelles comprennent des acides aminés spécifiquement murins, ainsi qu'à des acides nucléiques codant ces polypeptides. De plus, l'invention concerne des fragments et des variants biofonctionnels des TLR7 et TLR8 murins. En outre l'invention concerne des méthodes de criblage de ligands de TLR7 et TLR8, ainsi que des inhibiteurs, des agonistes et des antagonistes de signalisation médiés par TLR7 et TLR8.
Bauer Stefan
Lipford Grayson
Wagner Hermann
Coley Pharmaceutical Gmbh
Smart & Biggar
LandOfFree
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