A - Human Necessities – 61 – J
Patent
A - Human Necessities
61
J
A61J 3/00 (2006.01) A61K 31/66 (2006.01)
Patent
CA 2063058
A-1497-125 ABSTRACT A process is described for hydrating a lyophilized composition such as cyclophosphamide having a hydrated form as its most stable form and a bulking agent. The process comprises contacting the lyophilized composition with atomized water in a sealed chamber maintained at a reduced pressure, maintaining the relative humidity in the chamber at greater than 90% and, preferably, greater than 95% for a period of time sufficient to convert the composition to its most stable hydrated form, and recovering the hydrated composition.
Francis Daniel Lee
Palepu Nageswara Rao
Erbamont Inc. Dba Adria Laboratories
Gowling Lafleur Henderson Llp
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