Process for identification of genes encoding proteins having...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C07K 14/47 (2006.01) C07K 16/32 (2006.01) C12N 15/10 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2263744

The present invention is directed to selection systems for the identification of cell proliferation genes based on functional analysis. More specifically, the invention is directed to a process for the identification of a cell proliferation promoting activity, the isolation of genes involved in such cell proliferation promoting activity, and the use of the so identified genes for the diagnosis or treatment of a disease associated with excessive cell proliferation. The invention further is directed to the design and development of antibodies, peptides, nucleic acids, and other compounds which specifically interfere with the function of the identified gene and/or its gene product, and pharmaceutical compositions comprising such compounds, for the treatment of diseases associated with inappropriate or unregulated cell proliferation.

La présente invention a trait à des systèmes de sélection permettant l'identification de gènes de la prolifération cellulaire, fondés sur une analyse fonctionnelle. Plus spécifiquement, cette invention a trait à un procédé permettant l'identification d'une activité favorisant la prolifération cellulaire, à l'isolement de gènes impliqués dans une telle activité, et à l'utilisation des gènes identifiés par ce procédé dans le diagnostic et le traitement d'une maladie associée à une prolifération cellulaire excessive. Cette invention se réfère en outre à la conception et au développement d'anticorps, de peptides, d'acides nucléiques et d'autres composés qui ont une action spécifique sur la fonction du gène et/ou de son produit génique identifié, et à des compositions pharmaceutiques comprenant de tels composés, utiles dans le traitement de maladies associées à une prolifération cellulaire inappropriée ou non régulée.

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