C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/06 (2006.01)
Patent
CA 2574953
This invention is a process for improving the production levels of recombinant proteins or peptides or improving the level of active recombinant proteins or peptides expressed in host cells. The invention is a process of comparing two genetic profiles of a cell that expresses a recombinant protein and modifying the cell to change the expression of a gene product that is upregulated in response to the recombinant protein expression. The process can improve protein production or can improve protein quality, for example, by increasing solubility of a recombinant protein.
L'invention concerne un procédé permettant d'améliorer les niveaux de production de protéines de combinaison ou de peptides ou d'améliorer le niveau de protéines de combinaison actives ou de peptides exprimés dans des cellules hôtes. L'invention concerne un procédé permettant de comparer deux profils génétiques d'une cellule qui exprime une protéine de combinaison et de modifier cette cellule afin de modifier l'expression d'un produit génique qui est régulé en hausse en réponse à l'expression de la protéine de recombinaison. Ledit procédé permet d'améliorer la production ou la qualité d'une protéine, par exemple, par augmentation de la solubilité d'une protéine de recombinaison.
Jin Hongfan
Ramseier Thomas M.
Squires Charles H.
Dow Global Technolgies Inc.
Pfenex Inc.
Sim & Mcburney
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