Process for inhibiting the transcription of genes

Details Process for inhibiting the transcription of genes Process for inhibiting the transcription of genes

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/135 (2006.01) A61K 31/18 (2006.01) A61K 31/22 (2006.01) A61K 31/325 (2006.01) A61K 31/40 (2006.01) A61K 38/06 (2006.01) A61K 38/55 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) C07K 14/47 (2006.01) C12N 15/85 (2006.01) C12Q 1/37 (2006.01) C12Q 1/66 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2159822

Inhibition of the transcription of genes in higher eukaryotic cells by inhibiting the activation of NF-KB, wherein the cells are treated with substances which specifically inhibit the proteolytic degradation of IKB-.alpha. directly or indirectly. Process for screening substances which inhibit NF-KB activation by inhibiting the proteolytic degradation of IKB-.alpha.. Use of the substances for treating pathological conditions which can be traced back to undesirable gene expression controlled by NF-KB.

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