C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/604.2, 260/6
C07D 263/14 (2006.01)
Patent
CA 1272213
ABSTRACT OF THE INVENTION The invention relates to a process for inverting the configuration at the optically active carbon atom (*) in compounds of the formula I Image (I) in which A denotes a carbocyclic or heterocyclic aromatic radical and R denotes an aliphatic, cycloaliphatic or araliphatic hydrocarbon radical, by formylation, treating the resulting compounds with a strong acid or an acid halide and cleaving the oxazolinium derivatives thus obtained, by acid or alkaline hydrolysis, if appropriate via the stage of the N- formyl compound, and to oxazolinium derivatives of the formula III Image (III) in which A and R have the meanings defined above and in which X? represents the anion of a strong acid or of a halogen atom and formed as intermediate products. Compounds of the formula IV Image (IV) in which A and R have the meanings defined above, possessing the same structure as the starting material I but having an opposite configuration at the carbon atom (*), can be used as .beta.-blocking agents.
433790
Erle Hanns-Eberhard
Leuchs Hans-Jurgen
Mohler Werner
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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