C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 73/00 (2006.01) C07C 231/12 (2006.01) C07D 223/10 (2006.01) C07D 223/16 (2006.01) C07D 233/04 (2006.01) C07J 75/00 (2006.01)
Patent
CA 2049882
A novel, facile, and specific process for .alpha.-iodinating or .alpha.- brominating the .alpha.-methylenic carbon of an azasteroid, comprises reacting the amide with trialkylsilyl-X (R3Si-X), where X is Br, I, or Cl, and R is methyl, ethyl, or n-propyl, in the presence of I2 or Br2. The .alpha.-iodo- or .alpha.- bromo-amide is useful for making the .alpha.,.beta.-unsaturated amide through dehydrohalogenation.
Abramson Newton L.
Anderson Kevin
Karady Sandor
King Anthony O.
Shuman Richard F.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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