Process for iohexol manufacture

Details Process for iohexol manufacture Process for iohexol manufacture

C - Chemistry, Metallurgy

07

C

C07C 231/08 (2006.01) C07C 237/46 (2006.01)

Patent

CA 2265047

The invention provides a process for the production of iohexol (formula (1)) comprising reacting 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodophthalamide with a 2,3-dihydroxypropylating agent, the improvement comprising effecting that said process in the presence of a solvent comprising 2-methoxy-ethanol and, optionally, isopropanol.

L'invention concerne un procédé de production d'iohexol (formule (1)), qui consiste a faire réagir du 5-acétamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodophtalamide avec un agent 2,3-dihydroxypropylant; l'amélioration consistant en la mise en oeuvre de ce procédé en présence d'un solvant comprenant du 2-méthoxy-éthanol et, éventuellement, de l'isopropanol.

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