C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2092455
ABSTRACT OF THE DISCLOSURE The underlying genetic defect of Huntington disease (HD) has been mapped to chromosomal band 4p16.3. Refined localization using recombinant HD chromosome analysis and allelic association analyses have identified two distinct candidate regions. Using a cDNA hybrid selection procedure, .alpha.-adducin has been mapped to the proximal 2.2 Mb 4D gene candidate region within 20 kb of D4S95. Several clones have been mapped within the minimal region containing the HD gene. The clones GT 70 and GT 149 are particularly useful in detecting changes in this portion of the gene of HD patients.
Andrew Susan
Goldberg Paul
Hayden Michael
Rommens Johanna M.
Andrew Susan
Goldberg Paul
Hayden Michael
Rommens Johanna M.
Sim & Mcburney
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