Process for isolating igg and iga

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) C07K 1/14 (2006.01) C07K 16/00 (2006.01) C07K 16/06 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2242778

A process is disclosed for separating IgG and IgA from an immunoglobulin- containing starting material. The process is characterised in that: (i) IgG and optionally IgA are adsorbed on a solid inorganic carrier; (ii) IgA is extracted from the eluate, optionally after selective desorption, while IgG remains on the carrier; and optionally (iii) IgG is extracted from the adsorbate. Also disclosed is an IgA preparation with a low tendency to form aggregates.

L'invention concerne un procédé permettant d'isoler les immunoglobulines G et A (IgG et IgA) d'une substance de départ les contenant. Le procédé présenté est caractérisé en ce que: (i) l'IgG et éventuellement l'IgA sont adsorbées sur un support solide inorganique; (ii) l'IgA est extraite de l'éluat, éventuellement après désorbtion sélective, tandis que l'IgG reste sur le porteur; et éventuellement (iii) l'IgG est extraite de l'adsorbat. L'invention concerne également une préparation à base d'IgA ayant une faible tendance à la formation d'aggrégats.

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