Process for isolating tigecycline and tigecycline made...

C - Chemistry – Metallurgy – 07 – C

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C07C 231/24 (2006.01) A61K 31/65 (2006.01) A61P 17/00 (2006.01) C07C 237/26 (2006.01)

Patent

CA 2749981

The present invention provides a process for isolating tigecycline which process comprises the step of spray drying a solution of tigecycline in a solvent. Preferably the solvent is water or an organic solvent. In another aspect, there is provided tigecycline obtainable by spray drying, particularly in amorphous form. In particular, the invention provides tigecycline obtainable by spray drying according to the process of the invention.

La présente invention concerne un procédé pour isoler la tigécycline, procédé comprenant l'étape consistant à sécher par pulvérisation une solution de tigécycline dans un solvant. De préférence, le solvant est de l'eau ou un solvant organique. Selon un autre aspect, l'invention concerne la tigécycline pouvant être obtenue par séchage par pulvérisation, en particulier sous forme amorphe. En particulier, l'invention concerne la tigécycline pouvant être obtenue par séchage par pulvérisation selon le procédé de l'invention.

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