C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 17/18 (2006.01) C07D 498/18 (2006.01)
Patent
CA 2580127
The invention is a simple process for separation of tacrolimus and its analogues, ascomycin and tsucubamycin B and preparation of enough pure crystalline tacrolimus. The process takes advantage of surprising properties of tacrolimus and involves extraction, purification and crystallization to produce purified crystalline tacrolimus.
L'invention concerne un procédé simple pour séparer le tacrolimus de ses analogues, l'ascomycine et la tsucubamycine B, et pour préparer assez de trarolimus cristallin pur. Ce procédé tire avantage de surprenantes propriétés du tacrolimus et consiste à effectuer une extraction, une purification et une cristallisation, pour produire du tacrolimus cristallin purifié.
Blatny Pavel
Buchta Martin
Cvak Ladislav
Jegorov Alexandr
Satke Josef
Heenan Blaikie Llp
Ivax Pharmaceuticals S.r.o.
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