Process for isolation of macrolide compounds

Details Process for isolation of macrolide compounds Process for isolation of macrolide compounds

C - Chemistry, Metallurgy

12

P

C12P 17/18 (2006.01) C07D 498/18 (2006.01)

Patent

CA 2580123

Although macrolide compounds are insoluble in water, surprisingly high part of the product was found in the liquid phase of the fermentation broth. Therefore, processing the entire fermentation broth, i.e. the suspension obtained by cultivation of a microorganism producing the required macrolide compound, is highly advisable. This invention teaches a method of processing the entire fermentation broth using cheap and environmentally acceptable solvents.

Bien que les composés macrolides soient insolubles dans l'eau, une portion étonnamment grande du produit apparaît dans la phase liquide du bouillon de fermentation. Par conséquent, il est fortement recommandé de soumettre à un traitement la totalité du bouillon de fermentation, c'est-à-dire de la suspension obtenue par culture d'un micro-organisme produisant le composé macrolide requis. L'invention concerne un procédé permettant de soumettre la totalité du bouillon de fermentation à un traitement, à l'aide de solvants bon marché et acceptables sur le plan environnemental.

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