C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/073 (2006.01) C07H 19/06 (2006.01)
Patent
CA 2135853
An improved process suitable for large-scale production of 2',3'- didehydro-3'-deoxythymidine (d4T) and close analogs is disclosed. The unproved -process yields d4T in high yield and purity without the use of hazardous reactions or reagents and incorporates several process improvements important on a large scale including a novel purification step involving the isolation of a d4T.cndot.N-methylpyrrolidinone solvate.
Baker Stephen R.
Boyhan Brenda T.
Eisenreich Emerich
Skonezny Paul M.
Stark Derron R.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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