A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2478519
The present invention refers to a process of loading drugs in a thermodynamic activated form into polymers by means of supercritical fluids. The process includes a pre-treatment step of the cross-linked polymer with pure supercritical fluid to allow a higher degree and a more rapid kinetic of drug loading into cross-linked polymers and also a higher thermodynamic activation of the drugs.
La présente invention concerne un procédé de chargement de médicaments sous une forme activée thermodynamique, dans des polymères au moyen de fluides surcritiques. Ce procédé comprend une étape de pré-traitement du polymère réticulé avec un fluide surcritique pur de manière à obtenir un degré plus élevé et une cinétique plus rapide du chargement de médicaments dans des polymères réticulés et, également, une activation thermodynamique plus élevée des médicaments.
Bresciani Massimo
Dobetti Luca
Kirchmayer Stefano
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Eurand Pharmaceuticals Ltd.
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