C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 73/00 (2006.01)
Patent
CA 2050821
33/RJN16 18220 TITLE OF THE INVENTION NEW PROCESS FOR MAKING 17-BETA ALKANOYL 3-OXO-4-AZA-5-ALPHA-ANDROST-1-ENES ABSTRACT OF THE DISCLOSURE Disclosed is a new process for making 17-beta branched alkanoyl-3-oxo-4-aza-5-.alpha.-androst-1- enes, agents for treating benign prostatic hypertrophy (BPH), by reacting methyl 3-oxs-4-aza-5-.alpha.-antrost- l-ene-17-beta carboxylate with isobutylmagnesium bromide in the novel presence of hexamethyldisilazane (HMDS). Use of the EMDS results in higher yield and less by-products as opposed to the standard Grignard reaction in the absence of HMDS.
Merck & Co. Inc.
Swabey Ogilvy Renault
Williams John M.
LandOfFree
Process for making 17-.beta. alkanoyl... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for making 17-.beta. alkanoyl..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for making 17-.beta. alkanoyl... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1926493