Process for making 5-azacytosine nucleosides and their...

Details Process for making 5-azacytosine nucleosides and their... Process for making 5-azacytosine nucleosides and their...

C - Chemistry, Metallurgy

07

H

C07H 19/12 (2006.01)

Patent

CA 2733591

A process of synthesizing a 5-azacytosine nucleoside, such as azacitidine and decitabine, comprises coupling a silylated 5-azacytosine with a protected D-ribofuranose of formula in the presence of a sulfonic acid catalyst.

L'invention concerne la synthèse dun nucléoside de 5-azacytosine, tel l'azacytidine et la décitabine, comportant le couplage de 5-azacytosine silylée avec un D-ribofuranose protégé de la formule en présence d'un catalyseur d'acide sulfonique.

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