Process for making a cyclodextrin

C - Chemistry – Metallurgy – 08 – B

Patent

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C08B 37/16 (2006.01)

Patent

CA 2241774

Sulfoalkyl ether cyclodextrins are produced by a process of treating an unsubstituted cyclodextrin starting material with an alkyl sultone in the presence of a base. The base is added in a stepwise, pH controlled manner so that substantially the entire initial charge of cyclodextrin starting material is at least partially reacted. Additional base is then added to complete the reaction, and residual alkyl sultone is destroyed. The product advantageously contains low levels of both residual cyclodextrin and residual alkyl sultone.

Des éthers sulfoalkyliques de cyclodextrines sont produits par un procédé consistant à traiter une cyclodextrine non substituée comme matériel de départ avec une alkylsultone en présence d'une base. La base est ajoutée progressivement de manière à contrôler le pH, afin que la charge initiale entière de la cyclodextrine (produit de départ) ait au moins en partie réagi. On ajoute ensuite de la base additionnelle pour compléter la réaction, et le reste de l'alkylsultone est détruit. Le produit contient avantageusement de faibles concentrations à la fois de cyclodextrine résiduelle et d'alkylsultone résiduelle.

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