Process for making a skin marker for diagnosis by x-ray...

A - Human Necessities – 61 – K

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167/35, 167/46

A61K 49/04 (2006.01) A61K 49/18 (2006.01) G01R 33/28 (2006.01) G01R 33/58 (2006.01)

Patent

CA 1290244

ABSTRACT OF THE DISCLOSURE The present invention provides a process for making a skin marker for diagnosis by X-ray tomography and nuclear magnetic resonance imaging, comprising a casting step of casting into a vessel an aqueous solution containing more than 8 wt% and not more than 20 wt% of a polyvinyl alcohol having a degree of hydrolysis of not less than 98 mol% and an average polymerization degree of not less than 1,000, a non-magnetic and X-ray radioopaque material being dispersed in a wall of said vessel, a freezing step of cooling the cast aqueous solution to a temperature of not higher than - (minus) 10°C to obtain a frozen mass and a thawing step of thawing said frozen mass to obtain a hydrogel of high water content filled in said vessel.

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