Process for making an epoxide

Details Process for making an epoxide Process for making an epoxide

C - Chemistry, Metallurgy

07

D

C07D 413/06 (2006.01) C07D 263/52 (2006.01) C07D 413/02 (2006.01)

Patent

CA 2183976

A process for synthesizing the epoxide of formula (I) consists of, at a minimum, formation of a halohydrin form the allyl acetonide reactant, followed by base-induced cyclization, the epoxide product (I) being useful as an intermediate for the synthesis of inhibitors of renin or HIV protease or other proteases.

Un procédé de synthèse de l'époxyde représenté par la formule générale (I) consiste au minimum à former un halohydrine au moyen d'acétonide d'allyle utilisé comme réactif, puis à procéder à une cyclisation induite par une base, la substance époxyde (I) ainsi obtenue étant utile comme intermédiaire dans la synthèse des inhibiteurs de la rénine, de la protéase du VIH ou d'autres protéases.

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