Process for making camptothecin derivatives

Details Process for making camptothecin derivatives Process for making camptothecin derivatives

C - Chemistry, Metallurgy

07

D

C07D 491/22 (2006.01) C07D 491/147 (2006.01)

Patent

CA 2548543

A process for synthesizing highly lipophilic derivatives of camptothecin. The process includes reacting dissolved, underivatized camptothecin with a silylated heterocyclic compound in a modified Minisci-type alkylation reaction to produce 7-substituted derivatives of camptothecin.

L'invention porte sur un procédé de synthèse de dérivés fortement lipophiles de camptothécine consistant à faire réagir de la camptothécine dissoute non dérivée avec un composé hétérocyclique sylilé au cours d'une réaction d'alkylation de type Minisci donnant des dérivés de camptothécine substituée en 7.

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