C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/103, 204/91.
C07D 501/08 (2006.01) A61K 31/545 (2006.01) C07D 501/04 (2006.01) C07D 501/14 (2006.01) C07D 501/16 (2006.01) C07D 501/20 (2006.01) C07D 501/22 (2006.01) C07D 501/24 (2006.01) C07D 501/28 (2006.01) C07D 501/30 (2006.01) C07D 501/32 (2006.01) C07D 501/34 (2006.01) C07D 501/36 (2006.01) C07D 501/40 (2006.01) C07D 501/42 (2006.01) C07D 501/44 (2006.01) C07D 501/46 (2006.01) C07D 501/60 (2006.01) C07D 513/04 (2006.01)
Patent
CA 1057282
ABSTRACT OF THE DISCLOSURE A process is disclosed for preparing a cephalosporin of structure: Image (III) (III) where R is selected from the class consisting of hydrogen, alkyl having from 1 to 4 carbon atoms, cyano-methyl, thienyl-methyl, furyl-methyl, naphthyl-methyl, phenyl-methyl, phenoxy-methyl, phenyl-isopropyl, phenoxy-isopropyl, pyridyl-4-thiomethyl, tetra- zolyl-1-methyl; R1 is selected from the class consisting of hydroxy, alkoxy having from 1 to 4 carbon atoms, trichloroethoxy, benzyloxy, p- methoxy-benzyloxy, p-nitrobenzyloxy, benzhydryloxy, triphenyl- methoxy, phenacyloxy, p-halophenacyloxy; and Z is selected from the class consisting of hydrogen, hydroxy, -O-Alkyl, -O-CO-Alkyl, -Br, -I, -N3, -NH2, -O-COCH3, -O-CO-NH2, and an -S-mononuclear nitrogen heterocyclic ring, wherein a compound of structure: Image (I) where R, R1 and Z have the above meanings, is reacted with iodine in a suitable aqueous solvent at a temperature between 5° and 80°Cin the presence of an oxide of a heavy metal or with a free radical initiator under the influence of light or heat, to give a compound of structure: Abstract continued ... Image (II) in which R, R1 and Z have the above meanings, and the said intermediate (II) is reacted in a suitable sol- vent with a compound selected from the class consisting of in- organic and organic bases to finally give the desired compound (III) which is then isolated and purified in per se known manner.
232993
Foglio Maurizio
Franceschi Giovanni
Masi Paolo
Suarato Antonino
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