Process for making fluorinated 4-azasteroid derivatives and...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) C07J 73/00 (2006.01)

Patent

CA 2606595

The present invention relates to synthetic processes useful in the preparation of fluorinated 4-azasteroid derivatives of formula I that modulate androgen receptors and have application in the treatment of conditions caused by androgen deficiency or androgen receptor hyperactivity, such as osteoporosis, periodontal disease, bone fracture/frailty, erectile dysfunction, loss of libido, androgen-dependent cancers and sarcopenia. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

La présente invention concerne des procédés de synthèse utiles pour fabriquer des dérivés de 4-azasteroïde fluoré de formule I qui modulent les récepteurs androgènes et peuvent servir au traitement de troubles provoqués par une déficience en androgènes ou une hyperactivité des récepteurs androgènes, tels que l'ostéoporose, la parodontopathie, les fêlures/fractures d'os, les dysfonctionnements érectiles, la perte de libido, les cancers liés aux androgènes, et le sarcopénie. La présente invention concerne également des intermédiaires utiles dans les procédés de synthèse selon l'invention, et leurs procédés de fabrication.

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