Process for making galantamine

Details Process for making galantamine Process for making galantamine

C - Chemistry, Metallurgy

07

D

C07D 491/048 (2006.01)

Patent

CA 2683098

A novel process for the preparation of N-methyl-N-(2-[4- hydroxyphenyl]ethyl)-5-hydroxy-4-methoxy benzene carboxamide, which is useful as an intermediate in the synthesis of (-)-galantamine, comprises the reaction of a 5-hydroxy-4-methoxy benzoic acid derivative with N-methyl-N-(2-[4- hydroxyphenyl] ethyl) amine.

L'invention porte sur un nouveau procédé de préparation de N-méthyl-N-(2-[4- hydroxyphényl]éthyl)-5-hydroxy-4-méthoxy benzène carboxamide, utile en tant qu'intermédiaire pour la synthèse de la (-)-galantamine, ledit procédé comprenant la réaction entre un dérivé de l'acide 5-hydroxy-4-méthoxy benzoïque et le N-méthyl-N-(2-[4- hydroxyphényl] éthyl) amine.

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