Process for making hiv protease inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 413/06 (2006.01) C07D 263/52 (2006.01) C07D 453/02 (2006.01) C07D 471/04 (2006.01) C07F 9/653 (2006.01)

Patent

CA 2167183

A process for making a compound of formula I comprises reacting an epoxide of formula IV with an amine of formula V, wherein R1, R2, R3, R4, r and a are defined herein. Compounds of formula I are useful as HIV protease inhibitors. Image

On peut obtenir des intermédiaires de la formule structurelle (IV) en faisant réagir avec un amide du glycidol ou l'un de ses dérivés activés. Ce procédé et les intermédiaires qu'il permet d'obtenir sont utiles pour synthétiser des composés inhibiteurs de la protéase de VIH.

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