C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/44 (2006.01)
Patent
CA 2612844
The present invention is directed to a process for preparing certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
La présente invention concerne un procédé destiné à préparer certains composés d'hydroisoindoline utiles comme antagonistes des récepteurs de la neurokinine 1 (NK-1), ainsi que des inhibiteurs de tachykinine, et notamment la substance P. Ces composés sont utiles dans le traitement de certains troubles, y compris le vomissement, l'incontinence urinaire, la dépression et l'anxiété.
Huffman Mark A.
Journet Michel
Kuethe Jeffrey T.
Yin Jingjun
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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