Process for making intermediates for fragrance components...

C - Chemistry – Metallurgy – 07 – C

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C07C 45/66 (2006.01) C07C 45/72 (2006.01) C07C 45/74 (2006.01) C07C 45/82 (2006.01) C07C 49/21 (2006.01) C07C 49/242 (2006.01)

Patent

CA 2667608

A two-step aldol condensation process is disclosed. .alpha.-Campholenic aldehyde (ACA) and methyl ethyl ketone (MEK) react in the presence of a base under conditions effective to produce a mixture comprising a high yield of ketol condensation products. Dehydration of the ketols in the presence of an organic sulfonic acid provides unsaturated ketones that are valuable intermediates for fragrance components for synthetic sandalwood products. Compared with the usual one-step, base-catalyzed approach, the two-step process increases the yield of all condensation products and maximizes production of the most valuable ketone isomers.

L'invention concerne un procédé de condensation d'aldol en deux étapes. De l'aldéhyde .alpha.-campholénique (ACA) et de la méthyléthylcétone (MEK) réagissent en présence d'une base sous des conditions efficaces pour produire un mélange comportant un rendement élevé de produits de condensation de cétol. Une déshydratation des cétols en présence d'acide sulfonique organique fournit des cétones insaturées qui sont des intermédiaires de valeur pour des composants de parfum pour des produits de bois de santal synthétiques. Par comparaison à l'approche catalysée par une base en une seule étape habituelle, le processus en deux étapes augmente le rendement de tous les produits de condensation et maximalise la production des isomères de cétone de plus grande valeur.

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