C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/273 (2006.01)
Patent
CA 2660272
The present invention is directed to a process for preparing .alpha.,.alpha. disubstituted .gamma.-lactam derivatives of formula (I) that are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
La présente invention concerne un procédé servant à préparer certains dérivés de .gamma.-lactames disubstitués en .alpha.,.alpha. qui sont utiles en tant qu'antagonistes des récepteurs des neurokinines 1 (NK-1) et en tant qu'inhibiteurs de la tachykinine et en particulier de la substance P. Les composés sont utiles dans le traitement de certains troubles, dont les vomissements, l'incontinence urinaire, la dépression et l'anxiété.
Campos Kevin R.
Chen Cheng
Ishibashi Hideaki
Kato Shinji
Klapars Artis
Banyu Pharmaceutical Co. Ltd.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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