Process for making new derivatives of dimers of isoeugenol

Details Process for making new derivatives of dimers of isoeugenol Process for making new derivatives of dimers of isoeugenol

C - Chemistry, Metallurgy

07

D

260/367.1

C07D 307/86 (2006.01)

Patent

CA 1141392

ABSTRACT OF THE DISCLOSURE Compounds of the formula Image (IV) wherein R1 is selected from the group consisting of hydrogen, an unbranched or branched C1-C4 alkyl, halogen-substituted phenyl, and phenyl; R2 is hydrogen or phenyl; R3 is hydrogen or methyl; and R4 is selected from the group consisting of an unbranched or branched C1-C4 alkyl, an hydroxy-substituted unbranched or branched C1-C4 alkyl, allyl, and benzyl, are useful in the treatment of liver diseases, and for protection of the liver against damage. These compounds are prepared by reacting a dimer of isoeugenol of the formula (dehydrodiisoeugenol) Image (I) with an oxazolidine of the formula Image (III) wherein R1, R2, R3 and R4 have the same meaning as above. Where desired, pharmaceutically acceptable salts of the above compounds of formula (IV) may be prepared by reaction with an appropriate acid, e.g. hydrochloric acid.

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