Process for making oligonucleotides

Details Process for making oligonucleotides Process for making oligonucleotides

C - Chemistry, Metallurgy

07

H

260/210, 260/229

C07H 19/00 (2006.01) B01J 19/00 (2006.01) C07H 19/04 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01)

Patent

CA 1159052

ABSTRACT OF THE DISCLOSURE A process is described for removing trityl blocking groups from 5'-0 trityl nucleosides and oligo- nucleotides, this comprises contacting said nucleoside or oligonucleotide with a Lewis acid such as zinc bromide. The process is thus useful in synthetic processes for producing oligonucleotides and polynucleotides.

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