Process for making phenoxy benzamide compounds

Details Process for making phenoxy benzamide compounds Process for making phenoxy benzamide compounds

C - Chemistry, Metallurgy

07

D

C07D 231/40 (2006.01) C07C 317/22 (2006.01)

Patent

CA 2581619

A process for making a compound of formula (I), said process comprising a) reaction of a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X2 and ii) a compound of formula (IV) for example by nucleophilic aromatic substitution b) where necessary, conversion of X1 to a carboxylic acid; and c) coupling of the carboxylic acid group to an appropriate heterocyclic amine; wherein all variables are as defined in the description.

L'invention concerne un procédé de fabrication d'un composé de formule (I). Ledit composé comprend a) la mise en réaction d'un composé de formule (II) avec: i) un composé de formule (III) par substitution aromatique nucléophile de X2 et ii) un composé de formule (IV) par exemple par substitution aromatique nucléophile; b) lorsque cela est nécessaire, la conversion de X1 en un acide carboxylique; et c) le couplage du groupe acide carboxylique à une amine hétérocyclique appropriée; toutes les variables étant telles que définies dans la description.

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