Process for making (r)...

Details Process for making (r)... Process for making (r)...

C - Chemistry, Metallurgy

07

D

C07D 213/82 (2006.01) C07C 255/23 (2006.01) C07D 213/85 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2742785

The present invention relates generally to processes of making (R)-3-(2,3- Dihydroxypropyl)-6-fluoro-5-(2- fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, intermediates thereof, and a process for making a particular polymorph of (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4- iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine- 4,7(3H, 8H)-dione.

La présente invention concerne de façon générale des procédés de fabrication de la (R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophénylamino)-8-méthylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, ses intermédiaires et un procédé de fabrication d'une forme polymorphique spécifique de la (R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophénylamino)-8-méthylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione.

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