Process for making substituted piperidines

Details Process for making substituted piperidines Process for making substituted piperidines

C - Chemistry, Metallurgy

07

D

C07D 211/00 (2006.01) C07F 9/48 (2006.01) C07F 17/02 (2006.01)

Patent

CA 2591738

The present invention provides a process for the preparation of substituted piperidines which comprises an asymmetric hydrogenation of vinyl fluoride in the presence of a metal precursor complexed with a chiral mono- or biphosphine ligand.

L'invention concerne un procédé de préparation de pipéridines substituées, consistant à hydrogéner du fluorure de vinyle de manière asymétrique, en présence d'un précurseur métallique formant un complexe avec un ligand chiral monophosphine ou biphosphine.

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