Process for making taxane derivatives

Details Process for making taxane derivatives Process for making taxane derivatives

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) C07D 263/06 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2375834

The present invention provides a novel semi-synthetic method of producing a variety of novel taxane derivatives. The method involves the reaction of a phenylisoserine derivative with a suitably blocked Baccatin III derivative to produce a taxane substrate that may be further modified to form Pactitaxel and other potentially useful taxane derivatives.

La présente invention concerne une nouvelle méthode semi-synthétique de production d'une variété de nouveaux dérivés de taxane. La méthode comprend la réaction d'un dérivé de phénylisosérine avec un dérivé de Baccatine III bloqué de manière appropriée pour produire un substrat de taxane qui peut en outre être modifié pour former du Paclitaxel et d'autres dérivés de taxane potentiellement utiles.

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