Process for making trans-1-((1r,...

Details Process for making trans-1-((1r,... Process for making trans-1-((1r,...

C - Chemistry, Metallurgy

07

D

C07D 295/073 (2006.01) C07C 49/697 (2006.01)

Patent

CA 2597615

Described is a method for making the trans-1-((1R,3S)-6-chloro-3-phenylindan-1- yl)-3,3-dimethylpiperazine (formula I) and salts thereof and a similar method for making 4-((1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine (formula IX) and salts thereof, which method comprises conversion of a compound of formula IVa to the compound of formula I or the compound of formula IX, respectively.

L~invention décrit un procédé permettant de préparer la trans-1-[(1R,3S)-6-chloro-3-phénylindan-1-yl]-3,3-diméthylpipérazine (formule [I]) et ses sels, ainsi qu~un procédé similaire permettant de préparer la 4-[(1R,3S)-6-chloro-3-phénylindan-1-yl)-1,2,2-triméthylpipérazine (formule [IX]) et ses sels. Ledit procédé comprend la conversion d~un composé de formule (IVa), en composé de formule (I) ou composé de formule (IX), respectivement.

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