C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/18 (2006.01)
Patent
CA 2520714
The invention relates to a novel method for the production of telmisartan by reacting 2-n-propyl-4-methyl-6-(1'-methylbenzimidazol-2'-yl)-benzimidazol with a compound of general formula (IV), in which Z is a leaving group, wherein the compound 2-cyano-4'-[2''-n-propyl-4''-methyl-6''-(1'''-methylbenzimidazol-2'''- yl)benzimidazol-1''-ylmethyl]biphenyl is obtained, and subsequently conducting hydrolysis of the nitrile to acid function.
La présente invention concerne un nouveau procédé de production de telmisartan, lequel consiste à faire réagir du 2-n-propyl-4-méthyl-6-(1'-méthylbenzimidazol-2'-yl)-benzimidazol avec un composé correspondant à la formule générale (IV) dans laquelle Z représente un nucléofuge, cette réaction produisant le composé 2-cyano-4'-[2''-n-propyl-4''-méthyl-6''-(1'''-méthylbenzimidazol-2'''-yl)benzimidazol-1''-ylméthyl]biphényle, ce dernier étant soumis à une hydrolyse transformant la fonction nitrile en fonction acide.
Dach Rolf
Hauel Norbert
Heitger Helmut
Meyer Oliver
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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